Seconding Arq.
It's incredibly freeing to be able to dump your remote backups wherever you have space. Right now, the best for me is to send them to a virtual Linux box where I have enough space left.
It supports Amazon Drive, AWS, Backblaze B2, Dropbox, Filebase, Google Cloud, Google Drive, OneDrive, SFTP, SharePoint, Storj, Wasabi, network share or some other random S3-compatible server.
It's a native, let me repeat that, NATIVE Mac app and behaves exactly like one. Incredibly satisfying. Unlike Time Machine, it'll tell you what went right and what went wrong. I have a lifetime license.