Celebrity Deathmatch: Facebook vs. EC2

I'm wondering what the YC crowd thinks of Amazon's web services (S3 and EC2) as a means to handle Facebook traffic.

The pmarca blog entry about facebook intoned

"the Facebook Platform is primarily for use by either big companies, or venture-backed startups with the funding and capability to handle the slightly insane scale requirements. Individual developers are going to have a very hard time taking advantage of it in useful ways."

Can EC2 and a considered strategy to distribute load across [Amazon's] servers mitigate this?

Are there other tools and services that scale with usage in this way?

Anyone have experience with them?