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Comment by jacksnipe | Hacker News Reader

I think what you’re missing here is that generics are already approved with pretty large deviations in e.g. serum response from the underlying approved drug, but without re-testing.

So the current system is already producing bad-for-consumer outcomes at a rapid pace.

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Can confirm, the generic for the adhd med a couple of my kids take is super obviously not even close to as good as the real thing. Took us a little bit to put 2 and 2 together the first time we got that instead of the "real thing", but that was definitely the problem. Of course we still end up with the generic a lot, what with the shortage, and just have to deal with it barely-working instead of being wonderfully effective, until we get to roll the dice again 30 days later and hope we luck into name-brand pills being available.

Makes one wonder about, you know, all the other generics.

Is this a time release drug, like Concerta?

Yeah. The generics use a different ER mechanism, which is surely part of the problem, but others report issues with non-ER versions, too, presumably due either to purity/consistency issues or different filler material, so I doubt the ER difference is the only problem—we did use name brand non-ER at first before switching to extended release, and that wasn't even close to as ineffective as generics of the ER. I've read (but not confirmed) that some adhd generics are also allowed to use cheaper-to-manufacture almost-but-not-quite-identical isomers that haven't been tested and may have significantly worse efficacy, though, no clue if that affects ours (or if that's even true, really).

I wouldn’t be surprised. Concerta (osmotic time release) is so much more effective than normal generics (non-osmotic time release) that they shouldn’t even be considered the same drug.

Yeah, our experience is something like:

    unmedicated << generic <<<<<<<<<<<<<<<<<<<<<<<<<<<<< name brand

in terms of perceived effect. They're sure as hell not close enough to be considered equivalent under any reasonable classification scheme (but I assume insurers really, really, really want the generic to count as equivalent and work to ensure it is so-regarded—and, anyway, availability's so spotty that we just have to take what we can get regardless).

As a patient this was also my experience.

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