When the CSS is cached, this becomes ~200ms. Considering that the roundtrip is 168ms, this means that the vast majority of the pageload is just waiting for bytes to cross the atlantic. The roundtrip to eu-central is 30-50ms in comparison, less than 1/3rd. 3 times faster pageload is a significant UX difference.
Now, the reason we accept it with HN is that HN is just a list of direct anchor tags - the majority of the content is other websites. If the page had been more interactive, firing requests and dynamically fetching content, it would feel sluggish at best.
The difference in UX caused by latency is huge.