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> are selling a 5 in one capsule

As long as it's not known to be dangerous, people are free to experiment. But they should make it clear that there are no comprehensive studies showing an improvement, just speculation based on mechanics and some animal studies.

Another example is NAD+, people messing around with billion years old hyper-conserved mechanism (citric acid cycle). What could possibly go wrong, right?

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Ion channels are also a hyper-conserved mechanism as every cell needs to maintain a resting potential, and there are tons of ion channel modulating drugs approved and used messing with the with billion years old hyper-conserved mechanism.

I heard about NAD+ on Dave Asprey podcast, that with age the NAD cleavage system cleaving NAD excess is also degraded and a Nuchido company makes this supplement with additives targeting NAD cleavage system restore as well.

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