I'm not really sure what you mean by that - Zepto is a DOM editor and Backbone provides an MVC structure which represents the logical state of the UI. Higher-level organization in a Backbone app is accomplished by view composition.
If, however, you are referring to the weak link between Zepto-managed DOM and Backbone Views via hand-rolled render functions, then check out outback.js, a declarative data binding layer for Backbone in the same spirit as Knockout.js - well, more than spirit, the binding extensibility layer uses roughly the same API and much of the same documentation.