It used to be that you have to fiddle with a lot of fontconfig settings to get decent rendering results, but they've been shipping mostly sane defaults for quite a while now.
Hinting for some reason still has to be enabled manually, but very lightweight tools like `lxappearance` make that a single click, if you don't want to touch XML by hand.
For the past 15 years, my desktop has been
• openbox (also handles keyboard shortcuts etc., can be configured visually with obconf, which can also handle font settings iirc)
• picom (for compositing; before, the tools it was forked from)
• dunst (for notifications)
• arandr (for configuring external displays)
• flameshot (for screenshotting)
• Random LXDE bits as necessary (lxpanel at the absolute minimum, lxsession when I need to deal with polkit things, lxappearance sometimes)
It doesn't do much in terms of system configuration etc., but I didn't find I need much anyway these days. Printers etc. I no longer use, and most system settings can be configured with systemd's localectl/timedatectl once and left alone.