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I'd buy a Framework phone in an instant...

Yes. But what OS would it run out of the box? And what would you run on it?

GrapheneOS

I’d want to run Debian + Phosh.

Add sandboxed Android layer for apps compatibility and it would be next to perfect.

There is Waydroid. Not sure if it would be a good idea to ship with it installed, though. It would probably set expectations too high.