At the risk of descending into total newbie-land, when you say "do some research" where do you start with that? Has the state of things really moved to the point where I can find a highly rated ATX motherboard, a power supply that won't catch fire, and start plugging in components? My general approach would be to read reviews to find potential compatibility issues, stick with good performance but not bleeding edge, and to stay away from anything in the bargain basement.
(To everyone else who is replying about the 1Password replacement, +1 to all. Thanks. I'll check out those suggestions.)