I live in Southern California where there was no shortage (until recently, at least) of very early-stage startups, and for years I exclusively used startup-focused sites like AngelList (now Wellfound) when jobhunting. The largest startup had 12 people when I joined. I worked for a company of 40ish once, but they weren't primarily a tech company and engineering consisted of only 3 people.

I should perhaps disclaim that while this worked perfectly for me for close to a decade and I was never without work for more than a couple weeks at a time, I have currently been unemployed for a few months and have had a considerably more difficult time than at any point in the past.