Could this be embedded inside NodeJS thus eliminating the need for a driver?
It would be interesting to see the performance of Emscripten SQLite.
Can node.js and the V8 engine itself be compiled to JS? Could be interesting for sandboxing.
That way if you have some new type of architecture that's not supported by SQLite, but you do have a JavaScript VM available you could really easily whip up an SQLite based app without going to the trouble of porting SQLite itself.
If you're running Windows and can't compile the existing driver.