Yes, that's fine: if your domain is implementation detail of the system itself, then using Syndicate to allow different program components to have conversations about that domain is totally OK.
The point I was trying to make about exceptions and polluting the dataspace is as a point about unnecessary coupling: exceptions per se are not in most domains, so communications mechanisms that include exceptions as part of the transport are in some sense wrongly factored. Likewise transports that include sender information at the point of delivery of each received message. The point isn't that sender information or exception details aren't useful, but that they're not something to bake in.
Concretely wrt your example: you could use a dedicated dataspace for such things, yes, or you could design the language of discourse for a large shared dataspace to allow multiple ongoing conversations at once on unrelated or semirelated topics.