Or no zoning like in some cities in Texas. Where businesses usually, naturally gravitate towards busy intersections and shopping districts on their own.
My engineering ethics class covered a case in Houston, which has 0 zoning of any kind (or at least it did in the late 80's early 90's at the time of the events we covered. things might have changed) and the effects of putting a heavy metal incineration plant near government subsidized housing and elementary schools.