It's probably the end for our image of a dominant purely biological humanity. This isn't so bad or unexpected though. We are just the latest step in the universe's growing comprehension of itself.

At one point the self-replicating molecule was the most advanced cognition available in our little corner of reality, then at various times we had single celled organisms, colonial organisms, etc etc until eventually we got humans. There have been phase changes in the nature of cognition many times, this will just be the latest.

What comes next is just the latest link in a chain of continuous increasing complexity of life stretching back to the first time a couple of organic molecules reacted. It's exciting to be alive in a time when we get to see one of these phase changes. It's like being alive at the dawn of civilization or when the first fish crawled out onto land.