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Comment by criddell | Hacker News Reader

Thank you so much for sharing all of this. I've copied it to my phone so I can refer to it later.

I take quite a lot of vitamin D (6000 IUs daily), cetirizine (zyrtec), and nicotinamide riboside (300 mg), and a cheap multivitamin. I'm a little wary about adding stuff to that but I'm definitely going to look into all the things you've mentioned.

Psychedelics are super interesting to me but I really wouldn't know where to start. I'm 53 ferchrisakes. Last time I was around people buying mushrooms was 35 years ago at a skate park.

> just lend an ear

Say... that reminds me. Tinnitus isn't something you are dealing with as well, is it?

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Funny you mention it, I do have mild tinnitus. It’s also interesting to mentioned Zyrtec. There’s a whole subset of cluster research/sufferers that call them histamine headaches. I’ve wanted to explore anti histamines as a treatment but now that I have mine under control I hate to rock the boat. I know the psychedelics part is a lot, but there are several ways to tackle it. Growing magic mushrooms is very easy. Some people are also experimenting with LSA, which naturally occurs in seeds you can get online. I haven’t tried it but I imagine it could be effective. Another option I’ve considered is magic truffles. They’re legal in a lot of places due to their obscurity, but they contain psilocybin just like mushrooms. A micro dose that’s almost non perceptible every few months is enough to buy me years without headaches. It’s seriously amazing. Several well respected research hospitals and universities are digging into it right now. There’s definitely something to it. I imagine it has to do with the fact that they’re linking up with your 5-HT2A serotonin receptors. I believe they’re the same receptors that common anti migraine medicines bind to. Both psychedelics and migraine medicines fall into the triptan category of drugs. I’m definitely not a medical researcher and it’s been awhile since I did a deep dive on all this, so please verify/research anything I’m saying, but I hope I can at least point you in some of the right directions.

One last thing worth looking into is the link between vasodilation and cluster headaches. There seems to be a direct link. I think some of the theories are that the dilation of the major blood vessels in your brain pushes down on nerves like your occipital nerve. That seems to track with the areas I experience the most pain. I’ve experimented in the past with vasoconstrictors as a way to ease the pain. Both caffeine and psychedelics are vasoconstrictors for example. And they seem to be the two most agreed upon remedies. I believe exercise is also a vasoconstrictor, which may be why intense cardio seems to help me when the headaches start to come on.

I'll look into all of that. Again, thanks for sharing it all.

> Psychedelics are super interesting to me but I really wouldn't know where to start. I'm 53 ferchrisakes. Last time I was around people buying mushrooms was 35 years ago at a skate park.

Not sure where you live, but while not legal, you can order micro dose (100-200mg) mushroom capsules online in Canada.

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