Burn the house to kill the termites?
This graph of active dose to lethal dose ratio and dependence risk serves as a fairly good measure for the risk of various drugs in my opinion: https://upload.wikimedia.org/wikipedia/commons/a/a5/Drug_dan...
With drug-induced chronic psychosis a possibility (as with pretty much ALL more potent drugs), I am not sure "quite safe" is exactly the right word, despite the odds...