There's the MAPS MDMA study.

I'm also personally familiar with several (> 10) people who used MDMA to treat depression (other than PTSD), both independent of conventional psychotherapy and in a few cases in conjunction with it (by telling the doctor after independently dosing; since he's an MD he has a duty to care for the patient even if he's "on an illegal drug" at the time, but isn't at personal legal risk).

I would consider the long-term risks of 1-5 doses of MDMA over a year FAR lower than the side effects of prescribed antidepressants or other psychiatric medications on an ongoing or permanent basis. (I'm not a doctor, though. Just going based on observation of a not statistically significant number in both groups.)