It's not a straw man, it's a thought experiment. Obviously you can't actually do it. I'm sure you'd have trouble filling a room with rules about how to handle chinese symbols, or teaching a colourblind scientist everything it's possible to know about colour. It's hypothetical, it's a thought experiment.
Your first criticism is just invalid. The pill rewrites the workings of your brain to enjoy murder, the experience of murder and the consequences of murder. The fact that the brain originally evolved to work one way is irrelevant. The hypothetical pill changes the brain in a way just as powerful as the way an AI can rewrite its source code.
Your second criticism doesn't invalidate the experiment unless you claim that if the real life repercussions weren't a factor then you'd happily take the pill. I assume this is not the case.
Given all the facts, you won't choose to change what you fundamentally value, because that change would necessarily go against what you fundamentally value.