To be clear, they’re asking about having scrolling on a mouse and trackpad act differently from each other. The System Preferences / System Settings ‘Natural Scrolling’ option affects both mouse and trackpad, even though they’re in different places, and without third-party software it’s not possible to do what the commenter is asking.

Just to be pedantic, natural scrolling was introduced to OS X in 2011 with the release of Mac OS X Lion, 10.7.

Sounds like you haven't tried it out.