Also good luck in convincing Native Instruments and other musical instrument developers to also compile their plug-ins for Linux.
If you're already content with Reaper as a DAW, use "yabridge" which runs VSTs in WINE. It's virtually perfect for most purposes. Getting Linux audio set up for low latency is another Linux rabbit hole, though.
[0] https://lmms.io/ [1] https://surge-synthesizer.github.io/
The issue with most professional VST plug-ins is mainly the UI which is not compatible with Linux.
Go to Plugin Alliance [0] and select any plugin and when you scroll down you'll see that they are Windows and Mac only. Same for Plugin Boutique [1].
[0] https://www.plugin-alliance.com/en/products/amek_eq_250.html
[1] https://www.pluginboutique.com/product/1-Instruments/4-Synth...