It's easy to set up a new company, the overhead is minimal and there are lots of financial and other supports available from government agencies like Enterprise Ireland:
http://www.enterprise-ireland.com/en/
We have a very low corporate tax rate and the government recently introduced R&D tax credits to encourage innovation:
http://www.bdolimerick.ie/department.php?pg=/Research%20and%...
Not to mention a very strong academic community, plenty of funding available for academic collaboration and the presence of a huge number of prominent US tech companies including Google, Facebook, Twitter, eBay, PayPal...
http://thenextweb.com/insider/2011/11/26/what-attracts-big-t...