Careful, you might end up with the return of your Obra Dinner.

I had similar problem. I can't play Borderlands 2, but surprisingly turning off the comic outline effect in that game works. Obra Dinn is a great game, and I have to endure that by playing at the smallest resolution, which somewhat help. Also take frequent breaks, like 1-2 scene then hours of break. It help you think as well as I often found breakthrough by sleeping over the game.

The Case of a Golden Idol is a game in similar genre but in 2D, in case you can't get into this game. I'd say it's not better, but the last level in the main game is quite close to some of the harder puzzle in Obra Dinn.