Thing is, humans weren't there for nearly all of it. It's not a question of whether things change, it's a question of whether we can survive it as a species, or as a civilisation. Empires have risen and fallen throughout history, but it doesn't mean you'd rather live as part of a society in which you could die of a toothache instead of something more advanced.

It's going to get extremely unpleasant, it's a no brainer that we'd like to limit the fallout.