Descent had mouselook? Now I feel stupid. Or maybe I just didn’t have a mouse when I used to play it with friends, can’t remember.
The most popular choice of accessory was the Sidewinder 3D Pro. That was my choice of input device and I was easily a top 5% player in my teens.
I never touched one, but many people swore by the SpaceOrb 360 as the pinnacle of controllers for Descent.