Profile real world queries being run in production that use the most resources. Take a look at them. Get a sense of the shape of the tables that they're running against. Sometimes the ORM will be using a join where you actually want a subquery. Sometimes the opposite. Sometimes you'll want to aggregate some results beforehand, or adjust the WHERE conditions in a complex join. I've seen situations where a semi-frequent ORM-generated query was murdering the DB, taking 20+ seconds to run, and with a few minor tweaks it would run in less than a second.