Over the summer, however, I spend time in Spain. A town with a population under 200k, and yet far more dense than San Francisco. Streets are narrower, and most errands are less than 10 minutes away, on foot. The pharmacist, the baker, the workers at the restaurant, don't change very much. Since everyone walks, you really get to pass by every neighbor in the building every couple of weeks. The parks and playing ares with children are never close to empty, and people tend to have routines, so it's far easier to get to know people from random interactions. It's not uncommon to meet people you know, completely by accident, just because you walk the same streets. I might not stop at a certain coffee shop, but it has seating outside, and friends are be sitting there, and therefore I get a chance social encounter, even when I am not visiting the same business. There's benches in random streets, and people meet there, and chat on the street, so you don't even need a business as a "third place", when you have the street. Thus, getting six non-work social interactions a day becomes trivial.
Large parts of America have chosen forms of development that are naturally isolating: It's no surprise so many feel isolated!