There's some learning curve for features which exist for valid reasons, especially around communicating between domains. For instance, copy-and-paste between qubes requires extra steps. Plugging in a USB keyboard or mouse doesn't just work - you have to authorize it first (just click the OK button using a PS/2 mouse, or laptop's touchpad). You have to learn how to move files between qubes. USB drives, cameras, and microphones aren't globally available to all applications - you have to attach them to a qube first. You can install software using apt-get inside a qube, but it won't persist across reboots - you have to update the OS template.
I want those extra steps and complications - they are features, not a bugs! The first few days you'll be looking things up in the FAQ. After that it's pretty easy.
There are a few sore points that don't go away. You don't get GPU acceleration in your web browser, so rendering is slower. Gaming is not an option. Your application qubes live behind a firewall qube, so things that require network broadcast like Chromecast won't work. Those are fine for me but not for everyone.