I think you’re spot on about the clear advantage of your approach relative to the article and blood biopsies: If you’re looking for cancer in the blood, you’re probably too late as this suggests metastatic spread.

You suggest something better: look for tissue level markers.

The immunotherapy revolution (ie CTLA/PD1 molecules), you’ll recognize that leveraging the immune system is brilliantly effective.

Presumably stealth genes do not evolve first, but rather proliferative genes. And this is why any chronic damage triggers cancer because renewal is a replicative process, and replications begets copy errors. wanderers and passersby will have to recognize I’m simplifying.

I have a great lateral. Not sure if you have the funds to try two things, but TCR characterization is a wonderful idea. At least thats the best way to do it, as I see it. has many application beyond cancer

Good luck!