The frame tubes do have open ends. Especially on Van Moof bikes [1]. So I assume the components slide through the ends. Gear components from the bottom. Electronics from the front and back. So I don't see fundamental physical issues? Maybe this style will be more standardized by some companies at some point.
1: https://s.yimg.com/os/creatr-uploaded-images/2020-05/c54c62b...