Do you have any other experience (jobs from when you were in college) to be sure this is a problem unique to the job?

If you're in the Bay Area (or maybe NYC): Once you decide to quit, you should feel a lot better -- then take a couple days off to rest, find some worthwhile companies to talk to, etc. You should have interviews and a job within a week, which could be explained as "the flu".

If you're not in a hot startup job market, you either want to relocate before looking, or find a new job first. I do not think I'd quit my job in Indiana before having a new job in Indiana assuming I wouldn't leave Indiana. Sorry :(