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Histidine helps remyelinate the nervous system. If holes appear in the myelin sheath electrical signals wont get past the holes.

Lack of B6 can cause peripheral neuropathy which has symptoms like you describe. Can be linked to diabetes, some metals and B6 deficiency.

Conversely, in supplementing individuals, there's also B6 toxicity which has generally the same symptoms.

I've run into this when doing a more complex stack and neglecting to check the level of the B6 in the various sources.