Really sorry to hear this. I know it’s frustrating (I really do) but keep trying.

Over the course of 25 years I tried 42 different anti-depressants (practically all of them across all classes), atypicals, mood stabilizers, off-label Parkinson’s drugs, off-label anti-seizure drugs, benzodiazepines, you name it. Often multiple times (because time, age, etc) in incredible varieties of combinations, dosages, etc, etc.

The 43rd changed my life.

It’s rough, frustrating, and long but you need to keep trying keys until one (or more) fits the lock. Whether that’s these kinds of medications, ketamine, mushrooms, therapy, selling your worldly possessions and becoming a monk, whatever.

It doesn’t really matter how you do it - it’s life or death.

Try ketamine. It's been shown to work well for people for whom other things haven't worked (and for others).

Easily available online (at the moment) through telemedicine from places like this one https://www.joyous.team/ (no affiliation) that charges $129/mo.

Keep trying. I don’t want to give you false hope, but it’s entirely possible that you’ve just gotten unlucky for a variety of reasons.

It’s worth keeping in mind that long ago I was prescribed Prozac but didn’t take it consistently, so I didn’t notice any effect. It wasn’t until I did it every day for 60 days that I noticed changes. It’s like https://youtu.be/D8BZPAeCGEc?si=xjYSD9t5DprFfMRm but easier, since you just need to take a pill every day.

So keep consistent, and keep your head up. I believe in you.

Have you tried the prescription thyroid hormone supplement liothyronine (T3)? There’s some good evidence that it boosts the effects of antidepressants and may have antidepressant properties on its own.