Twitter bootstrap is awesome. I wish I could justify redoing my site using it but right now too much else going on. If you are developing Facebook apps, also check out f-bootstrap. It's based on Twitter bootstrap, but the styles and colors are more similar to Facebook's: https://github.com/ckrack/fbootstrapp
I am rewriting my site with its css now. Actually, i can build everything with js and css, but i cant make good looking things. TB for me is the way to prettify my ugly markup.
It is very friendly. I have to revise tons of javascript written without any mvc, but TB is built on classes. So, for the most parts i have to just install ids in tags required to drive my code.
Best Thing About Using Bootstrap is,
One doesn't have to worry about cross-browser issues. :)
That Makes Awesome Themes Like CandyClouds Possible...
here...
Take a Look.
http://wrapbootstrap.com/theme/candy-clouds-WB00781A8
and help me by making it more awesome., by buying it :)
Bootstrap is the new Photoshop Lens Flare.
It's not, but I understand what you're trying to convey. It's spreading like a wild fire and everyone is starting to use it -- but the default look has become very stale and played out (much like the lens flare). There's a lot being done to give users alternate styles, from free color styles and editors to premium themes.
I was going to put in a section about the staleness of the default layout used by many, many startups (I've certainly made many jokes about it), but I felt that would be out of scope. It is certainly a bad tactic from a branding perspective (it's not unique), but that's a thing that can be iterated upon.
As Bootstrap becomes more popular, theme developers will flock to it (like Wordpress and Tumblr before it).