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Express is really nice. I was surprisingly productive almost immediately after I started using it, and enjoyed it throughout.

I've been using Backbone.js for MV'C' in Node.js and re-using my models on the client side.

Backbone actually looks pretty good.

Also, Geddy might be just as good if not better than backbone.

I've also found Grasshopper to be a great one: https://github.com/tuxychandru/grasshopper

If you prefer a synchronous style (using fibers), I ported Stick from RingoJS: https://github.com/olegp/stick