Speaking from my own personal experience, I learned to touch type (properly) on QWERTY first, but after a while I switched to Colemak. After yet another while, I switched to Dvorak, and have been using it for several years now. For me, Dvorak has been slightly more comfortable than Colemak (which, in turn, was much more comfortable than QWERTY); though I have to admit I’ve never experienced significant pain or cramps just from typing. In any case, I find both layouts to be a great improvement over QWERTY, and certainly not only because of touch typing.