I'd just like to comment that, having built a medium to large Flask app over the last year, I would never recommend it as a framework for non-trivial sites.

I don't even want to sum up the amount of time that Django would have solved my problem instantly, but instead I had to pull my hair out dealing with Flask's global variables, circular dependency issues, and general lack of cohesion or standards. I think it's a great micro-framework if you're writing a one-python-file personal site or blog. Anything larger than that and you're going to regret it.