What problems did you run into? I've been using MacPorts for years at this point since Homebrew can never seem to install libraries in a way that pkg-config, gcc, and ld can find them. (Yes, I'm aware there is a subcommand in brew to manually print the paths to libraries, this is still not ergonomic compared to MacPorts where I install a library and it more or less "just works" when I want to use it).
Also, Homebrew attempting to nuke /usr/local on uninstall left a quite bad taste in my mouth. I had installed MacTeX before Homebrew, and thankfully MacTeX had proper file permissions set up, so my TeX installation was left in-tact. Still scary knowing that this is just done in the background without warning (unless the operation fails with errors).