"AI combined with CRISPR precisely controls gene expression" (2023) https://phys.org/news/2023-06-ai-combined-crispr-precisely-g... :

> Sanjana's lab teamed up with the lab of machine learning expert David Knowles to engineer a deep learning model they named TIGER (Targeted Inhibition of Gene Expression via guide RNA design) that was trained on the data from the CRISPR screens. Comparing the predictions generated by the deep learning model and laboratory tests in human cells, TIGER was able to predict both on-target and off-target activity, outperforming previous models developed for Cas13 on-target guide design and providing the first tool for predicting off-target activity of RNA-targeting CRISPRs.

Would TIGER also work with NICER?