They're largely harmless. Some of them seem pointless or purely resisting-change, like disabling menu bar transparency. Subpixel font rendering could look pretty bad on the wrong screen.

A lot of those Finder options are just going to increase noise on the screen. It's rare that I ever need to know the full path of something in OS X. Either I'm already on the command line, or I just use Spotlight.

Disabling the “Are you sure you want to open this application?” dialog seems just wrong. Confirming once per program downloaded from the net seems like a sane default.

Anyway these are pretty subjective things. Good thing they're so easy to pick and choose from and revert.