Anecdotally, on a desktop machine with something like 64GB RAM, when I switched from non-ECC to ECC (and 128GB RAM), the number of unexplained crashes seemed to drop from one every couple of weeks to one every 6 months or so. Could have been from a software upgrade though, probably Ubuntu 18 to Ubuntu 20.

Now I'm on an M1 MBP with 32GB RAM, and I get unexplained crashes roughly every 3-4 months, but I've been chalking it up to MacOS. Behavior also seems to degrade after a month or two of uptime. Hmm, maybe it's time for Apple to go ECC ...