How do networks manage the larger number of IPv6 addresses?

My cursory digging indicates that the secret sauce is to grant large IPv6 prefixes and delegate routing to the prefix. An informative-looking Reddit comment says there are 100k IPv6 prefixes (as of Oct. 2020), and each active route takes 1 KiB. [1]

So, IPv6 differs significantly from MAC addresses because you only need to track prefixes.

[1]: https://old.reddit.com/r/networking/comments/j9twgq/how_much...