Implying a mid-life crisis is an ad hominem based on some ageist shit. “Oh, disregard what he’s saying, it’s just a midlife crisis.
But he's certainly not saying "disregard what he's saying, it's a midlife crisis", he gives countless other reasons why Andreeson should be disregarded... not least because he's already profited enormously off of the techno-optimism of the past and doesn't give any reasons why trusting him with future techno-optimism will turn out any different.