Better than to hand-wave them wouldn't you agree? Because these issues are real, hard and very limiting factors, and they don't go away by throwing money at them. And I'm pretty sure I am not the only person who keeps raising these issues.
> Serious plans involve sending hundreds of rockets every year
That would be a really neat trick.
Mars's synodic period with Earth is 780 days (about 26 months) and the resulting transfer window lasts a few weeks at most. So if you want to send even 100 rockets per year, you have to start +200 rockets within that launch window.
To put that into perspective, since 1960 there were a grand total of 50 Mars missions, that includes unsuccessful ones, which were more than half: https://en.wikipedia.org/wiki/List_of_missions_to_Mars Most of these missions didn't land anything on Mars, and not a single one involved landing the spaceship itself, or had even remotely the kind of payload capacity that a colonisation effort requires.
So unless someone has a workable idea for a completely new propulsion system, I'm afraid there won't be "hundreds of rockets every year".
Edit: Oh, I almost forgot, small question: How do these "hundreds of rockets per year" get back to Earth? Because, if they don't, well, that's gonna up the launch costs somewhat, wouldn't it?