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Ooh, this is definitely something to play around with tomorrow. A split-tunnel on my phone would be nice!

Yup! Now we're thinking alike. Split only DNS and bingo, native ad blocking.

Would you give more explination please? How are you plannin on setting it up?

Run wireguard on your phone. Follow instructions for split tunneling. Only tunnel the IP of your DNS (PiHole) and boom.

Besides self hosting, is there anything this gives you that using NextDNS with a personal blocklist and adblock turned on can't do?

Not really, other additional than privacy.

Not routing every request through a single third party service?

Right, that's the self hosting part.