Assuming this is related to the AdSense thingy on the front page at the moment ... I think a decent amount of the problem is Google has virtually non-existant quality control.

I'd start by not approving all the scrapers and spammers and scammers. I'd avoid sites that get the majority of their traffic from reddit/etc, if they don't have natural traffic but they're consistently featured on social media sites they're probably spammers.

Once you take all the trashy people and their trashy sites out of the equation I think it would become a lot easier to detect fraud.

I would focus on:

1) high quality publishers

2) more interesting formats ... people used to talk about banner blindness, these days AdSense has to be pretty much shoved between sentences to be seen

3) actual support

Something probably like The Deck but more open.