It is wild to see disappearing polymorphism appear on the front page of HN! My company, Lavo Life Sciences (W23) is building software to predict polymorphism in drug molecules, happy to answer any questions on this thread :)
Are there any promising paths towards preventing this? Seeding clean rooms with other chiral molecules that can encourage the lost higher energy form of a crystal, maybe?
It also makes you wonder if novel crystal forms could be discovered by purposely seeding the process with other arbitrary seeds.
I wonder if you could also detect it using some other harmless but otherwise volatile material?
I think there was another post about this a few days ago. IIRC the title was about a specific drug affected by it.