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Someone has started: https://github.com/baconization/d16x

And:

I was going to write one using DynASM (it would be very short, simple, and fast) but it was unclear to me that DCPU-16 had any substantial programs written for it where you could show off a speed difference.

I have been looking for an excuse to write an article about how to use DynASM though.

I'd like to see an implementation in OrgASM, but it's hard to type with just one hand.

JIT compiling DCPU-16 bytecode using LLVM is something I plan to do later if I get time. I imagine by then someone else will already have done it, but if not, then its something I plan to do.