author shrugged this off pretty easily but nicotine is a vasoconstrictor which is an issue when combined with it being addictive. that's a problem if you ever have certain types surgery due to wound healing and lack of blood flow. There's more than a few people that effed their plastic surgery results because they immediately went back to nicotine. (note: not all plastics are necessarily volunteer, such as after certain cancer/tumor/melanoma removals).