Llms do stuff that has value. I can use Rfdiffusion with motif scaffolding to create a fusion protein with units from enzymes that have no crystal or cryoem structures with as high as a 5-10% success rate!!!!!! That's absolutely insane! I only need to print 20 genes to have a chance of getting a variant that works. Literal orders of magnitude improvement. And if you don't have a good multisequence alignment for getting a good folks from alphafold? Pure llm based esmfold can fill in the gaps. Evodiff is out here generating functional proteins with disordered regions. Also, to bring it back to openai, if I ask chatgpt to write some code, it writes some pretty decent code. If I give it a bunch of PDFs and ask it to give me a summary, it gives me a summary. I don't buy the agi end of the world hype so a shift that means that we get more focus on d eveloping useful tools that make my life easier that I'm totally willing to pay 20 a month for? Yeah I'm down. Get this cool tech and product into a form that's easy to use and useful and keep improving it!