These are all downstream from the points mentioned.
> Personal problems are political problems. There are no personal solutions at this time. There is only collective action for a collective solution. (Carol Hanisch, 1970)
If you think strictly unidirectional, you‘ll end up at the Big Bang as the root of all suffering, and what would that achieve?
That’s besides the other factors I mentioned - if you look at studies of what substances pathogens in the stomach and microbiome produce, it turns out they can really cause anxiety. My take is that anxiety can be a multifactorial issue and a local minimum that one needs to climb out of actively. Accepting life as suffering might not give the impulse to get the necessary help.